Why are cationic amino acids involved in the interaction with DNA?
DNA is negatively charged. This is the reason why, cationic or positively charged amino acids (eg. Arginine and Lysine) are involved in the interaction with DNA. The negative charge of DNA is due to negatively charged phosphate groups in the backbone of DNA. There will be repulsion between similar charges (between positive-positive charge and negative-negative charge). When a negatively charged amino acid come in contact with DNA, there will be repulsion because of the negtive charge of the DNA. Because of these reasons, positively charged or neutral amino acids are more involved in interacting with DNA
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