Question

Prolonged type II diabetes can eventually lead to type I. Place the events leading to this transition into their correct order. (Hint: start with e) (8 points)

a) Apoptosis is triggered, β cells die, and insulin secretion ceases. b) The increased levels of ATP resulting from glucose metabolism alter the voltage across the cell membrane. c) Insulin is not utilized correctly by the other cells. d) Ca2+ enters the β cells and triggers the release of insulin. e) Glucose absorption and metabolism by the β cells of the pancreas. f) Unfolded protein response (UPR) in the pancreas. g) The β cells respond to insulin resistance by trying to synthesize and secrete more and more insulin.

Answer 1

The steps would be as below"

e) Glucose absorption and metabolism by the β cells of the pancreas.

b) The increased levels of ATP resulting from glucose metabolism alter the voltage across the cell membrane.

d) Ca2+ enters the β cells and triggers the release of insulin.

c) Insulin is not utilized correctly by the other cells.

g) The β cells respond to insulin resistance by trying to synthesize and secrete more and more insulin

f) Unfolded protein response (UPR) in the pancreas.

a) Apoptosis is triggered, β cells die, and insulin secretion ceases.