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How does Group A Streptococcus Pyogene enter the host?

How does Group A Streptococcus Pyogene enter the host?

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How does Group A Streptococcus Pyogenes enter the host?

  • ​S. pyogenes contains several virulence factors (example Pyrogenic exotoxin A, B and C, M-proteins, Streptococcal superantigen, lipoteichnoic acid) that play an important role in evading the host immune response and attachment to host tissue.
  • S. pyogenes is present as a normal flora in the respiratory tract of the individuals (~5-15%). However, in instances where the individuals immune system is compromised or suppressed then these organisms can penetrate the defense system and cause infection. It can cause skin infections throat infections, suppurative and non suppurative diseases.
  • The primary site of invasion is the throat (pharynx) causing pharyngitis or strep throat.
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