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2. Explain the three dimensional structure of collagen 3. What is the specialty of the amino...

2. Explain the three dimensional structure of collagen

3. What is the specialty of the amino acid glycine in conferring its structure to collagen

4. How has collagen been used in cosmetics and why is it not common in recent years

5. What are the alternative to collagen injections

6. How is collagen used to prepare artificial skin for burn patients

7. Write the structures of two unusual hyroxylated amino acids that are present in collagen and why are they important component of its structure

8. What is scurry and why is it caused?

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Answer #1

2. Collagen fiber is approximately 300nm long and having a width of 1.5 nm. This is made up of three polypeptide chains. Three left handed helical polypeptides wind around to form a right handed triple collagen fiber molecue. This follows a regular pattern of aminoacids Gly-Pro-X or Gly-X-Hyp.

3. Glycine accounting for 1/3 of the aminoacid sequence in this fiber. Due to the smaller size of the aminoacid, it does not occupy much space in the tightened triple helical structure. This helps in the stabilisation of the triple heical collagen structure during cross linking and hydrogen bond formation.

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