Question

Explain the functional value of pyruvate oxidation and its importance in generating building blocks for biomolecules.

Answer 1

In the presence of oxygen, pyruvate is exported into the mitochondria where it is oxidized to produce Acetyl Co-A.

This step connects glycolysis to the next steps in the aerobic respiration.

Acetyl Co-A enters TCA cycle to produce NADH, FADH2 and GTP.

Acetyl Co-A is the precursor for the biosynthesis of fatty acids.

Acetyl Co-A --------> Malate ----------> Carbohydrates

Acetyl Co-A --------> Cholesterol ----------> Bile salts and Steroids

Acetyl Co-A --------> Isopentenyl pyrophosphate ----------> Ubiquinone, Vitamin A, E and K.

Acetyl Co-A transfers an acetyl group to the TCA cycle. Many of TCA cycle intermediates serve as precursors for both glucogenic and ketogenic compounds.