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Heart muscle contains a form of PFK-2/FBPase-2 that is different from that in liver. In heart...

Heart muscle contains a form of PFK-2/FBPase-2 that is different from that in liver. In heart muscle, phosphorylation of PFK-2/FBPase-2 by protein kinase A (also called cAMP-dependent protein kinase) activates PFK-2 and inhibits FBPase-2. Explain why this makes metabolic sense for a response of heart muscle to epinephrine. (Heart muscle cells have receptors for epinephrine, but not for glucagon.)

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During condition like fear, anger etc there is an increase in production of epinephrin which increases herat rate, blood pressure, cardaic output and carbohydrate metabolism. This is called "fight or flight" condition. During these processes there is an extra need of energy and the immediate source of energy is glucose. Therefore epinephrin released causes the phosphorylation of PFK2 via protein kinase. This leads to an increase of priduction of fructose 2, 6 bisphosphate. The latter is an activator of enzyme of glycolysis which increases rate of glycolysis and more energy production meets the energy needs of "fight and flight" conditions

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