Question

Increase/Decrease/No Change. Answer in the space provided: éfor “increase” or “greater than” , êfor “decrease” or “less than”, and   = for "no change" or “no difference” or “not affect”

26. At physiological pH, the amino acid glycine will have a ___________ dipole moment (μ) than the oligopeptide Met-Tryp-Ala-Ile-Pro.

27. A carbon atom and a hydrogen atom are brought in closer proximity than their van der Waals contact distance. This will _________the attraction between these two atoms compared with the attraction at atoms’ van der Waals contact distance.

28. Increasing the pH in a solution of aspartic acid will _________ the ratio of [aspartate]/[aspartic acid].

29. Making the ΔG of an enzyme-catalyzed reaction more negative will ______ the rate of the reaction.

30. Conformational entropy (S) _________ when a protein folds.

Answer 1

30. Decreases - folded proteins are reactive than denatured proteins, this is because when protein folds both entropy and reactivity increase while stability decreases.

29. Not affect- this will make the process spontaneous, that means it will just tell if the reaction will proceed or not but won't tell about the time taken.

28. Increase- when pH is increased that means acidic character is decreased by additiiaof base, aspartate is aspartic acid without its carboxylic hydrogen. Since base is added so aspartic acid will give it's carboxylic hydrogen and turn into aspartate, so ratio increases.

27. Decrease- if two atoms are brought in proximity, then their external electron clouds repel each other, so attraction decreases.

26. Lesser- dipole moment is the product of charge and separation between charges, so given oligopeptide has higher dipole moment than glycine.