Question

Biology of Stem Cells. Thanks!

What key transcription factor and signaling protein drives MSC osteogenesis versus adipogenic differentiation

Answer 1

Transcription factor and signaling protein drives MSC osteogenesis:

The major transcription factors are CBFA-1/Runx2 and Osterix. There are also other factors and signalling molecules involve in this process including HOXB7, CBF-1α, TNF-α, FOXC2, YAP, HOXA2, BMP9 and β-catenin, DLX5. Wnt, BMP, and Notch signaling pathways also play a crucial role. Smad, BMP9 promotes the activation of Smad1, 5, and 8 and osteogenic differentiation.

Transcription factor and signaling protein drives MSC adipogenic differentiation:

The major transcription factors are PPARγ1, PPARγ2 and EBF-1. There are also other factors and signalling molecules involve in this process including CEBPB, PRDM16, Twist-1, Dermo-1, COUP-II, Sox2 and Oct4.