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Why do DNA mismatch repair enzymes preferentially repair bases on the newly synthesized DNA strand, using...

Why do DNA mismatch repair enzymes preferentially repair bases on the newly synthesized DNA strand, using the old DNA strand as a template?

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Answer #1

DNA mismatch repair enzymes are strand specific.DNA mismatch repair enzymes preferentially repair bases on the newly synthesized DNA strand using the old strand as template for two reasons:

  1. If the old strand is corrected, important genetic information in the old strand may get lost or changed.
  2. Also, if the old strand is repaired using the new strand, the error may become permanent mutation in the genome.

Also if the mismatch is repaired in the old strand, there will be a 50% chance that mutated (daughter) strand is used and 50% chance that original (parental) strand is used as template for repairing. In total this amounts to no repairing at all.

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