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Describe the mechanism in BACTERIA for repair of DNA containing mismatches, chemically modified bases, and double...

Describe the mechanism in BACTERIA for repair of DNA containing mismatches, chemically modified bases, and double strand breaks. List sources for thumbs up, please.

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Answer #1

Mechanisms in the bacteria for the repair of

1. DNA containing mismatches :

Mismatch repair mechanism

In this mechanism it recognizes the incorrectly placed nucleotides in the DNA

Mut S, Mut H and Mut L - cleavage of the mismatched nucleotide

Exonuclease - excision of the mismatched nucleotide

Ligase - sealing of the DNA after excision of mismatched nucleotide

In this way , the mismatched nucleotide is removed from the DNA

2. Chemically modified bases :

DNA glycocylase - recognizes the chemically modified bases

Endonuclease - cleavage of the chemically modified bases from the phosphodiester backbone

DNA polymerase 1 - to correct the DNA base

3. Double stranded breaks : has 2 mechanisms .they are

A. Homologous recombination - no loss of nucleotide

B. Non-homologous end joining - loss of nucleotide

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