Question

How would you experimentally identify which subset of the sequences in the 7-kb fragment are required...

How would you experimentally identify which subset of the sequences in the 7-kb fragment are required for the normal expression of wg?

Homework Answers

Answer #1
  • In general , to test which fragment expresses a particular protein or enzyme , the gene can be cut into fragemnts and expressed in a plasmid .
  • the plasmid should also contain , a GFP , antibiotic resistance sites to selectively grow the cells that contain only the fragment.
  • By precisely deleting certain fragemnts and joining them , we can also detect which genes whether upstream or downstream elements control the expression of particular fragment.
  • So, here the 7kb fragment should be cut precisely and selectively and ligated with plasmid .
  • The plasmid which contains the gene will alos contain GFP6 protein.
  • When the plasmid constructs are transffered to cultured cells or embryos , the expression of the gene can be studied.
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