Question

Identify diseases that are caused by defects in Microtubules , kineisn , Dyenin or other motor proteins.

Disease

Defect in which domain of protein

what function is lost? what is the consequence of that at the cellular level and organ level.

Answer 1

Tau protein which is a microtubule binding protein hyperphosphorylated, in the brain of Alzheimers disease. The domain of the protein is proline-rich domain.

Kinesin defect have been identified as the cause for Charcot-Marie-Tooth disease and in some cases, some kidney diseases. Kinesin protein have central alpha-helical coiled coil domain.

Dynenin defect have been identified as the cause for neurodegenerative disease. Human Cytoplasmic Dynein 2 is the domain present in dynein