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Explain why blocking the inhibitory G protein from deactivating adenylate cyclase can be deadly.

Explain why blocking the inhibitory G protein from deactivating adenylate cyclase can be deadly.

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Answer #1
  • Adenylate cyclase is the enzyme which catalyses the formation of cAMP from ATP. Inhibitory G protein (Gi) blocks activity of adenylate cyclase and stops production of cAMP.
  • If adenylate cyclase is not deactivated by Gi, then cAMP would be continously made.
  • Increased cAMP levels would lead to greater Ca2+ influx into neurons leading to their hyperpolarisation.
  • cAMP levels also trigger release of hormones like adrenaline & nonadrenaline.
  • Thus, if inhibitory effect of G protein is blocked then continuous production of cAMP would lead to imbalances in neuronal system as well as hormonal system. This can be deadly.
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