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Under what circumstances would a genomic DNA library be preferable to a cDNA library? What about...

Under what circumstances would a genomic DNA library be preferable to a cDNA library? What about the reverse (when might you want a cDNA library)?

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A genomic library is a collection of the total genomic DNA from a single organism. Genomic libraries are commonly used for sequencing applications. They have played an important role in the whole-genome sequencing of several organisms, including the human genome and several model organisms.

cDNA libraries are commonly used when reproducing eukaryotic genomes, as the amount of information is reduced to remove the large numbers of non-coding regions from the library. cDNA libraries are used to express eukaryotic genes in prokaryotes. A cDNA library represents a collection of only the genes that are encoded into proteins by an organism. Complementary DNA, or cDNA, is created through reverse transcription of messenger RNA, and a library of cDNAs is generated using DNA cloning technology.

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