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If a patient has a deficiency of Na+ linked histidine transport protein. Anticipate the level of...

If a patient has a deficiency of Na+ linked histidine transport protein. Anticipate the level of histidine in the following; (write high or low concentration) What is the level of histidine in the patient’s blood? What is the level of histidine in the patient’s urine?

2) Biochemistry

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Answer #1

Na+ linked histidine transporters such as SLC6A19 are neutral amino acid transporters that help in the absorption of amino acids like cysteine, tryptophan, and histidine from the intestine. They are also essential for the reabsorption of these amino acids back after filtration from renal tubules.

therefore, if there is a deficiency in the Na+ linked histidine transport, enough levels of histidine cannot be absorbed ( it is an essential amino acid), and also, out of whatever level is absorbed, quite a lot is lost via urine due to a lack of reabsorption.

So, under conditions of deficiency of the transporter,

The blood level of histidine is low.

The concentration of histidine in urine would be high.

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