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Differentiate the roles of the two different phosphorylation sites of insulin receptor substrate 1 (IRS1). Include...

Differentiate the roles of the two different phosphorylation sites of insulin receptor substrate 1 (IRS1). Include the specific amino acids that are phosphorylated as well as the signaling pathway involved in your answer

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Answer #1

ANSWER:-

IRS1 has multiple phosphorylation sites (Ser/Thr/tyr). Chief among them are Ser307, Tyr628, and Ser632.

1. Phosphorylation at Tyr608 promotes docking of phosphoinositide-3-kinase (PI3K), a downstrem effector of IRS1 (insulin signalling), thereby inducing PI3K,AKt signalling.

2. Phosphorylation at Ser307, Ser612 inhibits IRS1 function. Phosphorylation at Ser307 removes IRS1 from insulin receptor and decreases Tyr608 and Tyr628 Phosphorylation leading to its degradation. Phosphorylation at Ser612 and Ser632 undocks PI3K thereby reducing PI3K/Akt signalling.

Tyr - Tyrosine

Ser - Serine

Numbers (e.g. 307) means amino acd position in the IRS1 protein

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