Question

PLC converts PIP2 (phosphatidylinositol-4,5-bis phosphate) to DG (diacylglycerol) and IP₃ (inositol-1,4,5-trisphosphate), leading to inhibition of PLD (phospholipase D).

true or false?

Answer 1

Phospholipase C (PLC) is the membrane bound enzyme which helps in the cleaving of phospholipids. Thus PLC converts PIP2 to DAG and IP3. Both DAG and IP3 are used as secondary messengers for various functions of the cell.

PIP2 is the main cofactor for the activation of phospholipase D (PLD). Researches proved that degradation of PIP2 directly inhibits the activation of PLD.

Hence PIP2 is cleaved by PLC into IP3 and DAG Or DG results in the inhibition of PLD.

Therefore the statement given in the question is True.