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.  PLC converts PIP2 (phosphatidylinositol-4,5-bis phosphate) to DG (diacylglycerol) and IP3 (inositol-1,4,5-trisphosphate), leading to inhibition of PLD...

.  PLC converts PIP2 (phosphatidylinositol-4,5-bis phosphate) to DG (diacylglycerol) and IP3 (inositol-1,4,5-trisphosphate), leading to inhibition of PLD (phospholipase D).

A)    True   

B)    False

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Answer #1

Answer: B) False

Explanation:

Plospholipase C hydrolyzes the bond between the glycerol moiety and the inositol-1,4,5-triphosphate. This results in the formation of Diacylglycerol (DAG) which remains bound to the membrane, and the IP3 (inositol-1,4,5-triphosphate) which is a secondary molecule free to move in the cytosol. IP3 causes activation of the calmodulin via calcium ions. This then causes the CaM-Kinase to get activated.

The pathway is nowhere related to the inactivation or inhibition of Phospholipase D (PLD)

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