Question

PLC converts PIP2 (phosphatidylinositol-4,5-bis phosphate) to DG (diacylglycerol) and IP3 (inositol-1,4,5-trisphosphate), leading to inhibition of PLD (phospholipase D).

true or false

Answer 1

Yes it is true...PLC converts PIP2 (phosphatidylinositol-4,5-bis phosphate) to DG (diacylglycerol) and IP3 (inositol-1,4,5-trisphosphate), leading to inhibition of PLD (phospholipase D).

PLC will selectively catalyzes the hydrolysis of the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) on the glycerol side of the phosphodiester bond. There is the formation of a weakly enzyme-bound intermediate, inositol 1,2-cyclic phosphodiester, and release of diacyl glycerol (DAG). The intermediate is then hydrolyzed to inositol 1,4,5-trisphosphate (IP3). Thus the two end products are DAG and IP3.Leading to inhibition of pld.