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A patient recently underwent a transplant and first shows success. About two months after the surgery...

A patient recently underwent a transplant and first shows success. About two months after the surgery the patient comes in with complaints and issues are arising due to the transplant surgery. What type of hypersensitivity is occurring? How would you distinguish which type of rejection is taking place? Please explain in detail.

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Answer #1

Tissue rejection occors in case of allografting not in autografting. Type IV hypersensitivity is often called delayed type hypersensitivity as the reaction takes two to three days to develop. Unlike the other types, it is not antibody mediated but rather is a type of cell-mediated response.Cell midiatied immuity for which T lymphocytes are responsible plays a major role in tissue rejection.Exposure of bloodmarrow and lymph nodes to X radiation inhibits blood cell production and thus slows down rejection. also immunosuppresents like cortisol are helpful.

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