all of the above.
when blood glucose level starts to decrease toward lower than normal, alpha cells of the pancreatic islets secrete glucagon.
Glucagon plays a major role in maintaining blood glucose levels by activation of hepatic glycogenolysis and gluconeogenesis. Glucagon and epinephrine markedly stimulate the breakdown of glycogen in muscle and liver. The liver is more stimulated by glucagon whereas muscle is more stimulated by epinephrine. The enzymatic activity of glycogen phosphorylase, principle enzyme in glycogenolysis, is regulated by these two hormones.
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