Question

PRE-LAB QUESTIONS

1. List the functions of the skeletal system.

2. What material contributes the most to the compressive strength of bone?

3. Briefly describe the process of bone remodeling.

4. Research Wolff’s Law. How does the formation of torus mandibularis relate to this theory?

5. Given your understanding of Wolff’s Law, what mechanical consideration would be important when designing a bioreactor for osteocyte growth ex vivo?

Answer 1

1. There are six major functions performed by the skeletal system
a. Structural support
b. Movement
c. Protection to internal organs
d. Production of blood cells
e. Storage of minerals
f. Endocrine regulation

2. The compressive strength of bones is contributed by two compounds
a. Calcium carbonate
b. Calcium phosphate

3. Bone remodeling is a life-long process that involves bone resorption and ossification.
It is an active continuous process that occurs in a healthy body.
Resorption = Mature bone tissue is removed from the skeleton
Ossification = New bone formation
These processes are responsible for the maintenance of bone structure, repair, and health.
Several hormones (Ex: PTH) vitamins (vitmin D), and growth factors (M-CSF) regulate bone remodelling.
Osteoblasts = Produce new bones
Osteoclasts = Abosrb bone tissue during healing and growth