Question

Compare glycolitic pathways with ; 1) aerobic glycolysis in blood stream trypanosomes. 2) hydrogenosomal pathway in...

Compare glycolitic pathways with ;
1) aerobic glycolysis in blood stream trypanosomes.

2) hydrogenosomal pathway in trichomonads

Science   Anatomy-And-Physiology   
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Answer #1

Dear Student,

1) Glycolytic pathway is highly active in treponema.Blood stream of trypanosomes depend completely on glycolysis for their ATP supply.

Pyruvate is considered as the sole end product under aerobic conditions , with the redo balance by a shunt acting to regenerate DHAP to G3PD. And also glycolysis in the parasite is different from that of the host, and this is the reason why many drugs target this pathway for the treatment of African Sleeping Sickness.

2)Hydrogenases are double membraned organelle present in place of mitochondria because trichomonas lacks mitochondria .

Pyruvate is formed through glycolysis in the cytoplasm, which are sent to Hydrogenosomes . In Hydrogenosomes, they get metabolised to acetate and Carbon-di-oxide and ATP is formed by substrate level phosphorylation.

Hope this makes you clear...

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