Question

A newly discovered hormone X is determined to be structurally similar to cholesterol. Predict how this...

A newly discovered hormone X is determined to be structurally similar to cholesterol. Predict how this new hormone interacts with its target cells.

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Answer #1

Being structurally similar to cholesterol, hormone X will be a non-polar, lipid soluble, steroid hormone. So, it will be able to freely diffuse through the lipid bilayer of the plasma membrane of the target cells and directly bind to intracellular (intracytoplasmic) receptors specific to hormone X (may be called nuclear hormone receptors) and bring about its effect, which can be gene transcription. Cortisol and sex hormones testosterone and estrogen are also derivatives of cholesterol (steroid hormones) and they interact in this manner with their target cells.

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