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Psuedohypoparathyroidism describes a disorder with a loss-of-function mutation of the Gs for parathyroid hormone receptor. What...

Psuedohypoparathyroidism describes a disorder with a loss-of-function mutation of the Gs for parathyroid hormone receptor. What would be the plasma levels of calcium, phosphate, and PTH in a patient with this disorder and why?

Science   Anatomy-And-Physiology   
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Answer #1

1).PTH( Parathyroid hormone )along with Vit D act on osteoclast and leads to resorbtion of Bone releasing Calcium from bone into blood .

2) Intestine : PTH incraeses calcium and phsophate absorption by increasing active form of Vit D.

3.)Kidney : Decrease calcium excretion and increase phosphate excretion.

*So main function of PARATHYROID hormone is to increase Calcium levels in Blood and Decrease phosphate levels.

*When there is deficiency of PARATHYROID hormone it is known as Hypoparathyroidism .

*So PTH action is not there so blood Calcium levels will decrease and Increase phosphate levels in Blood

Decreased PTH ----->Decreased Calcium + Increased Phosphate in blood

*In case of Pseudohypoparathyroidism ,PTH levels in Blood is normal but the receptors on which it act is defective so although PTH levels are normal but PTH actions on tissues will not take place .

*Pseudohypoparathyroism occur when there is loss of function mutation of G stimulatory action of receptors through activation of Adenylate cyclase and releasing Cyclic AMP.

*So blood levels of Calcium is Decreased as PTH can not cause resorption of bone releasing Calcium from bone into blood because of defective PTH receptor .

*Also Phosphate levels increased in blood as PTH normally cause Phosphate Excretion through kidney no PTH action no Excretion of phosphate so increased Phosphate .

*As PTH is secreted from Parathyroid glands and it is normal so PTH is secreted more and more because of resistance to PTH receptor and blood levels of PTH is Increased

Disease Calcium in blood Phosphate in blood PTH levels in blood
Parathyroidism Decreased Increased Decreased
Pseudoparathyroisism Decreased increased Increased

2 Types of Parathyroidism 1) Type 1 A

1. Type 1 a will have Bone mineral changes

2. IT causes Albright Hereditary Osteodystrophy

3.Characterised by short stature,round facies,Mental retardation,Short 4 th Metacarpal>>>Metatarsals

2) TYPE 1 B won't have any Bone mineral changes .

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