Suppose in January 2006 you conducted a study in a subsidized housing community in the Boerum Hill section of Brooklyn, NY. You enrolled 1000 residents in your study and checked on their tuberculosis (TB) status on a monthly basis. At the start of your study on January 1st, screening of the entire study population revealed that 25 of the healthy residents were immigrants who were vaccinated for TB and so were not at risk. Another 45 residents already had existing cases of TB on January 1st. On March 1st, 7 residents developed TB and 20 others were lost to follow-up (LTFU). On April 1st, 5 more residents developed TB. On May 1st, 32 residents refused to participate any further, thus they were withdrawn (LTFU). On July 1st, 5 additional residents developed TB. On August 1st, 10 healthy residents moved away from NYC and were LTFU. On September 1st, 9 residents developed TB. On October 1st, 11 of the residents who had existing TB on January 1st died from their disease. On November 1st, 1 resident developed TB. The study ended on December 31, 2006. Assume that once a person gets TB, she has it for the duration of the study, and assume that all remaining residents stayed healthy and were not LTFU.
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