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A person has been born with a mutation that results in a deficiency in the production...

A person has been born with a mutation that results in a deficiency in the production of MHC I by all of their cells. How might this deficiency affect a person immunologically?

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Answer #1

EFFECT OF CONGENITAL DEFICIENCY OF MHC1:-
- Viral infection after a latent period.
- chronic bacterial infection of upper respiratory tract, may extent to lower respiratory tract.
- most common bacteria are staphylococcus, streptococcus, E.coli, klebsiella, Pseudomonas etc.
- skin infection may be seen either in childhood or adult may be pustules, ulceration, granuloma etc.
- In some cases infection of central nervous system are also seen. E.g Wegener's granulomatosis.

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