Question

1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply):

-The patient will have a scarcity of CD4+ T helper cells

-MHC class I molecules will not be expressed to any extent on the patient’s cells

-MHC class II molecules will be reduced in expression

-The patient will have an impaired ability to fight viral infections

-The patient will have a scarcity of CD8+ cytotoxic T cells

Answer 1

The patient will have a scarcity of CD8+ cytotoxic T cells.

The patient will have an impaired ability to fight viral infections.

Because TAP is required to transfer the antigen from cytosol into the endoplasmic reticulum where the MHC 1 is produced and antigen is also present and thus when MHC 1 is completely formed then the frangements of antigens bind with the MHC 1 AND BECOMES PRESENTED TO CD8 NAIVE CELLS AND AFTER THAT THE NAIVE TC BECOMES ACTJVE CTLS AND MAKES CLEARANCE OF VIRAL INFECTION.