Question

I have a couple of questions of topics that aren't 100% clear to me:

How might one use (R)-2-phenylpropanoic acid in a classical resolution scheme to separate a racemic mixture of 2-butanol into enantiomers? Use words and pictures to explain the specific steps you could use. (Hint: Consider the Fischer esterification and its reversibility)

Where would you expect EAS to be most favorable on 4-methylcatechol? Explainyour choice completely in terms of steric and electronic effects.

Thank you for any explanation ahead of time!

Answer 1

iriversible reaction of ester is shifted to right by simultenious removal of water formed in the reaction, as it does not hydrolysed ester to back acid .

in the final step we can hydrolysed ester to get pure alcohol.