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what properties are desirable in a derivative? Why does a liquid make a poorer derivative than...

what properties are desirable in a derivative? Why does a liquid make a poorer derivative than a solid?

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Answer #1

Several characteristics are desirable for a derivatization reaction:

  1. The reaction is reliable and proceeds to completion. Less unreacted starting material will simplify analysis. Also, this allows a small amount of analyte to be used.
  2. The reaction is general, allowing a wide range of substrates, yet specific to a single functional group, reducing complicating interference.
  3. The products are relatively stable, and form no degradation products within a reasonable period, facilitating analysis.
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