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biochem aspartic acid has a Pka of 4.5. in the active site of the lysozyme, Asp...

biochem
aspartic acid has a Pka of 4.5. in the active site of the lysozyme, Asp functions as a nueophile and is deprotonated. Will the pka be less than
4.5 or equal to it? explain
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Answer #1

Considering HA as protonated form of aspartic acid. It is having pKa of 4.5. when base is used to deprotonate HA, it becomes A- .

More the pKa lower will be the acidity. Now that HA has lost its H+ and there is no reason for it to have acidic character, it will show basic character which means lowered acidity.

Lower acidity means more pKa. Because Ka is dissociation constant of acid. More the acid dissociates, more acidic will be the solution.

pKa = -log (Ka)

Ans= pKa will increase.

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