Question

What is a chemical reason why the yield of  4-((benzylamino)methyl)-2-methoxyphenol from P-vanilin and benzylamine via reductive amination...

What is a chemical reason why the yield of  4-((benzylamino)methyl)-2-methoxyphenol from P-vanilin and benzylamine via reductive amination with NaBH4 is below 100%? Also in this reaction why would the crude of the imine be less than the purified imine, the imine is (E)-4-((benzylimino)methyl)-2-methoxyphenol.

Science   Chemistry   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

NaBH4 is good reducing agent in reductive amination.but not as much efficient.

First step will be nucleophilic addition of P-vanilin or benzylamine to the carbonyl group

It will covert into C=O to C=N

Mechanism of imine formation is diffrent.Possibility of dealkylation is more so NABH4 will be involved in the reductive amination to get E)-4-((benzylimino)methyl)-2-methoxyphenol..

There are two amines will be formed

primary and secondary

During the reaction various intermediate compounds will be obatined like enamines that why it is below 100% and purity also less than crude.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
For The Synthesis of Lidocane answer the following: 1.Why does α-chloro-2,6-dimethylacetanilide only precipitate after an aqueous...
For The Synthesis of Lidocane answer the following: 1.Why does α-chloro-2,6-dimethylacetanilide only precipitate after an aqueous solution of sodium acetate is added? 2.Chloroacetyl chloride is a lachrymator (induces tearing). Give the chemical reaction that occurs on the surface of an eye exposed to this lachrymator. What is the actual agent that produces the irritation and causes the eye to form tears? 3.What happens to the diethylamine that is not extracted from the organic layer when HCl is added and than...
(i) A solution of toluene (methyl benzene) and ethanoic acid is said to exhibit “positive deviations...
(i) A solution of toluene (methyl benzene) and ethanoic acid is said to exhibit “positive deviations from Raoult’s Law”. Discuss 1) how the graphical evidence obtained from partial pressure measurements as a function of composition would prove it exhibits positive deviations and 2) why it deviates using a molecular-based explanation. Please be specific to the system in question in your explanations. (ii) The acetone-cyclohexane system also exhibits positive deviations from Raoult’s Law. Sketch the expected temperature-composition phase diagram for this...
Reactions 1-4 below describe the industrial process used to synthesize sulfuric acid starting from sulfur, oxygen...
Reactions 1-4 below describe the industrial process used to synthesize sulfuric acid starting from sulfur, oxygen gas, and water. Reaction 1:    S(s) + O2(g) → SO2(g) Reaction 2: 2 SO2(g) + O2(g)  → 2 SO3(g) Reaction 3: H2SO4(l) + SO3(g) → H2S2O7(l) Reaction 4: H2S2O7(l) + H2O(l) → 2 H2SO4(l) Overall Reaction (1-4): 2 S(s) + 3 O2(g) + 2 H2O(l) → 2 H2SO4(l) A. The industrial production of sulfuric acid involves proper control of temperatures and flow rates of...
1. P(z<-2.12)= ? 2. P(z=2.6)=? 3. P(z>-3)=? 4. P(z<-2.36)=? 5. p(z>-0.24)=? 6. P(-1.88<z<1.65)=? 7. The mean...
1. P(z<-2.12)= ? 2. P(z=2.6)=? 3. P(z>-3)=? 4. P(z<-2.36)=? 5. p(z>-0.24)=? 6. P(-1.88<z<1.65)=? 7. The mean amount of sleep needed for adults is 509 minutes per night. If the standard deviation for adult sleepers is 47. What is the Z score associated with sleeping 556 minutes per night? Round your answer to the nearest thousandth. 8. The mean amount of sleep needed for adults is 502 minutes per night. If the standard deviation for adult sleepers is 43. What is...
It is from the book Elementary Principles of Chemical Processes, 4th Edition, Problem 5.66 The quantity...
It is from the book Elementary Principles of Chemical Processes, 4th Edition, Problem 5.66 The quantity of sulfuric acid used globally places it among the most plentiful of all commodity chemicals. In the modern chemical industry, synthesis of most sulfuric acid utilizes elemental sulfur as a feedstock. However, an alternative and historically important source of sulfuric acid was the conversion of an ore containing iron pyrites (FeS2) to sulfur oxides by roasting (burning) the ore with air. The following reactions...
1. An aircraft weights 120,000 lbs., it has 35,000 lbs. of fuel added. What will be...
1. An aircraft weights 120,000 lbs., it has 35,000 lbs. of fuel added. What will be its takeoff weight? If there is 350 lbs. of excess weight what will be its new weight? Hint 1 kg = 2.21 lbs. Gravity = 9.81 N/m (up to 5 points) 2. Why is the fracture value less than the UTS value shown on a stress-strain graph? (up to 5 points) 3. Use the table below that gives the yield point for three materials....
4) Why is it suggested, by evolutionary biologists, that the teleosts (and the other ray finned...
4) Why is it suggested, by evolutionary biologists, that the teleosts (and the other ray finned fish) share a common ancestor which was freshwater, even though many contemporary teleosts are marine? a) because the earliest fossil animals are found in freshwater strata, and since teleosts are animals, the earliest teleost must have been freshwater also b) because, unlike sharks, teleosts are highly-evolved, which means osmoregulating in a wide variety of environments c) because the bodily fluid osmolarities in teleosts and...
1. Suppose the market demand for Paradise Bakery's cookies is given by the equation P=45-(1/2)Q. What...
1. Suppose the market demand for Paradise Bakery's cookies is given by the equation P=45-(1/2)Q. What quantity sold would maximize the revenue from the cookies? 1-) 40 2- )45 3-) 50 4-) 55 5-) None of these are correct. 2. A monopolist enjoys a monopoly over the right to sell automobiles on a certain island. It imports automobiles from abroad at a cost of $10,000 each and sells them at the price that maximizes profits. One day, the island’s government...
What was the reason for the addition of H2O (10 ml), followed by gentle heating? Draw...
What was the reason for the addition of H2O (10 ml), followed by gentle heating? Draw a mechanism equation for the reaction taking place. Why was the water added slowly and through the condenser? Here is my experiment... Experimental procedure Warning: acetic anhydride is corrosive and a lachrymator. When carrying it across the lab, when it is inside a flask, please temporarily stopper the flask. Reaction Place salicylic acid (200 mg = 0.200g) into a dry 25ml round bottom flask...
1. Inflammation is generally a protective response, which would normally be beneficial. Is it an exclusively...
1. Inflammation is generally a protective response, which would normally be beneficial. Is it an exclusively beneficial response? Explain 2 pts 2. You are a physician and your patient has had a heart attack resulting in decreased blood flow to the heart tissue. Once blood flow is reestablished, what might be a major concern? 2pts 3. One of the first steps in inflammation is the development of increased adhesiveness of neutrophils to the endothelium cells of venules. How does this...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT