Question

For The Synthesis of Lidocane answer the following:

1.Why does α-chloro-2,6-dimethylacetanilide only precipitate after an aqueous solution of sodium acetate is added?

2.Chloroacetyl chloride is a lachrymator (induces tearing). Give the chemical reaction that occurs on the surface of an eye exposed to this lachrymator. What is the actual agent that produces the irritation and causes the eye to form tears?

3.What happens to the diethylamine that is not extracted from the organic layer when HCl is added and than when KOH is added? Detail the result after addition of each reagent.

4.Give two reasons why you might predict the second step % yield of lidocaine will be less than the first step % yield of -chloro-2,6-dimethylacetanilide.

Answer 1