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In de novo phospholipid biosynthesis, the activated intermediate is CDP-diacylglycerol generated from the reaction of phosphatidate...

In de novo phospholipid biosynthesis, the activated intermediate is CDP-diacylglycerol generated from the reaction of phosphatidate with CTP to yield the CDP-diacylglycerol and pyrophosphate. Based on the chemistry of this reaction, what would you expect to be the source of the two phosphates in the CDP-diacylglycerol?

a. It would be expected that both phosphates would be derived from CTP.

b. It would be expected that both phosphates would be derived from the phosphatidate.

c. One phosphate would be derived from phosphatidate and one from CTP.

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Answer #1

In all of these biosynthesis, and activated intermediate (UDP-glucose, CDP-diacylglycerol, or CDP-alcohol) is formed from a phosphorylated substrate (glucose-1-phosphate, phosphatidate, or phosphoryalcohol) and a nucleoside triphosphate (UTP or CTP).
The activated intermediate then reacts with a hydroxyl group )the terminus of glycogen, the side chain of serine, or a diacylglycerol).

So the Correct answer is C..i.e. One phosphate would be derived from phosphatidate and one from CTP.

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