Question

A Suzuki reaction requires palladium (0) to begin the catalytic cycle, yet this reaction uses palladium...

A Suzuki reaction requires palladium (0) to begin the catalytic cycle, yet this reaction uses palladium (II). Explain how palladium (II) is reduced to palladium (0) to start the reaction.

Homework Answers

Answer #1

The Suzuki reaction uses Pd(0). However, the reaction starts with a Pd(II) species like Pd(PPh3)4 or Pd(PPh3)2Cl2. The said Pd(II) species are known as catalyst precursors. The catalyst precursor is added to the reagent in presence of a base (like K2CO3 or trimethylamine, NEt3). Triethyl amine also acts as the solvent in the reaction.

The solvent reduces Pd(II) to Pd(0) in situ. Pd(0) species are highly reactive and hence, must be generated in solution. The mechanism of reduction of Pd(II) to Pd(0) involves the addition of NEt3 to Pd(II) to form a complex which undergoes dehydropalladation (loss of Pd(II)XH). The Pd(II)XH species undergoes reductive elimination with NEt3 to form Pd (0).

Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
PGI uses a histidine and a glutamate residue as acid-base catalysts during the catalytic cycle. Draw...
PGI uses a histidine and a glutamate residue as acid-base catalysts during the catalytic cycle. Draw a single mechanism for the reversible PGI-catalyzed reaction. Indicate the flow of electrons for the forward (glycolytic) direction using solid arrows and that for the reverse (gluconeogenesis) direction using dashed arrows
A. The food industry often uses catalytic hydrogenation to convert double bonds in the fatty acids...
A. The food industry often uses catalytic hydrogenation to convert double bonds in the fatty acids of the oil triacylglycerols to -CH2-CH2-. How does this affect the physical properties of the oils. Which form provides greater energy upon combustion? Please explain your answers. B.)How is it possible for some molecules to be at equilibrium across a biological membrane and yet not be at the same concentration on both sides?
At AJAX Chemical, INC. a critical reaction requires the solubility of PbCl2 to be minimal in...
At AJAX Chemical, INC. a critical reaction requires the solubility of PbCl2 to be minimal in a critical patented reaction. As one of the staff chemists, it is your job to find the molar solubility of this salt in a solution that is also 0.1180 M in cesium chloride, CsCl. The Ksp of lead(II) chloride is 1.70e-5. The correct answer is 0.00122. Please explain how to get to this question.
1. What is an ISP (Integrated Service Provider) for supply chains? (1 point) A. A consultant...
1. What is an ISP (Integrated Service Provider) for supply chains? (1 point) A. A consultant agency which integrates the supply chain for companies B. A 2 PL or a 3PL, but not a 4PL C. A company supplying transportation and warehousing services D. A logistics service company specialized in suppling VAS (value added services) 2. What characterizes a 4 PL? (1 point) A. They are non-asset based and provides integrated services primarily supplied by asset based providers, for example...
READ THE CASE STUDY AND ANSWER THE FOLLOWING QUESTIONS 2nd CASE: An Unexplained Death A 65-year-old...
READ THE CASE STUDY AND ANSWER THE FOLLOWING QUESTIONS 2nd CASE: An Unexplained Death A 65-year-old man of Scandinavian descent was rushed to the Emergency Room of your local hospital after a family member discovered him unconscious in his home. The woman who dialed “911” told the dispatcher that the man, her brother, was the local librarian of the past 10 years and had no spouse or children. She reported that they had spoken the day before, and he had...
Sign In INNOVATION Deep Change: How Operational Innovation Can Transform Your Company by Michael Hammer From...
Sign In INNOVATION Deep Change: How Operational Innovation Can Transform Your Company by Michael Hammer From the April 2004 Issue Save Share 8.95 In 1991, Progressive Insurance, an automobile insurer based in Mayfield Village, Ohio, had approximately $1.3 billion in sales. By 2002, that figure had grown to $9.5 billion. What fashionable strategies did Progressive employ to achieve sevenfold growth in just over a decade? Was it positioned in a high-growth industry? Hardly. Auto insurance is a mature, 100-year-old industry...