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What’s a haplotype? Why is it sufficient to test one SNP when three (PAV vs AVI)...

What’s a haplotype? Why is it sufficient to test one SNP when three (PAV vs AVI) determine the phenotype?

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  • A haplotype is a pattern of sequential SNPs (single nucleotide polymorphisms) on a single chromosome that tend to be inherited together and are used as a set of markers.

Why is it sufficient to test one SNP when three (PAV vs AVI) determine the phenotype?

  • The PAV haplotype is associated with the phenylthiocarbamide (PTC) and its chemical relative, 6-n-propylthiouracil (PTC/PROP) tasting phenotype and the AVI haplotype is associated with the non-tasting phenotype. The ability to taste PTC/PROP is a polymorphic trait.
  • Since tasting" is dominant over "nontasting", therefore, anyone who has at least one SNP should be able to taste PTC or PROP compounds and because of it, it is sufficient to test one SNP.
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