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Does genotype have an effect on mobility? If yes, how so? Explain

Does genotype have an effect on mobility? If yes, how so? Explain
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Yes!!! genotype have an effect on mobility as explained by an example of hemoglobin chains.

The hemoglobin chains shows different electrophoretic mobility in individuals with different genotypes such as wrt S and A alleles.
The Glu→Val substitution causes a charge difference between Hb-A and Hb-S so causes the mobility of the molecule in an electric field

The SS and AA homozygous genotypes produces a single band even then shows different electrophoretic mobility.

The electrophoretic phenotype of AS heterozygotes is the sum of the phenotypes of the two homozygotes. So the phenotype produced with each allele in homozygous conditions is fully expressed in the heterozygote condition as well. So A and S alleles are codominant.

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