Question

Why the hydrolytic scission of phosphodiester linkage is an important process and how it stabilizes DNA and RNA? Thankyou for answering with clear detail

Answer 1

The hydrolysis of phoshodiester bonds is important for the energy relase required for the joining of nucleotides in both DNA & RNA. How ever this lysis plays an important role in repairing DNA sequences which is being catalysed by the phosphodiesterase enzyme. DNA is more stable than RNA due to the abscence of OH(hydroxyl) group at 2nd Carbon position, since the phosphodiesterases act on OH group.Where as presence of OH group at 2nd carbon position makes RNA more susciptible to the reaction.