Question

when RTKs bind their ligand this results in the activation of the _____ and ________ 1....

when RTKs bind their ligand this results in the activation of the _____ and ________

1. GPCR; acitvation of a g protein

2. GPCR: Autophosphotylation

3. Diner; Autophosphotylation

4.Diner; acitvation of a g protein

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Answer #1

Tyrosine kinase receptors (RTK) are group of cell surface receptors that are involved in the signal transduction pathway. Binding of the signaling molecule, ligand with the receptor induces the kinase activity. This will result in the conformational change of monomer receptor to dimerise. This will leads to the phosphorylation of tyrosine residue in the cytosolic domain, which will later results in the autophosphorylation of the receptor itself.

Hence option 3 is the correct one.

when RTKs bind with their ligand this results in the activtion of the dimer and autophophorylation.

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