Question

When ligands such as growth factors bind to receptor tyrosine kinase (RTKs), they may regulate cellular proliferation by activating

Select one:

a. Cyclin dependent kinases (CDKs)

b. Beta/gamma subunits of G-proteins

c. GDP

d. Transcription factors

e. Alpha subunits of G-proteins

Answer 1

When ligand such as growth factor binds to receptor tyrosine Kinase (RTKs) , they may regulate cellular proiferation by activating
a) Cycin dependent Kinases
explanation: The binding takes place to instigate plethora of biochemical reactions culminating in regullation of cell fate. Molecular mechanisms that regulate growth factor signal transduction, incuding growth factor structure and its mutation , ligand binding and growth factor dimerisation, as wel as the signalling pathways lead to G1 cell cycle progression. The induction of Cyclin D expression , CDK4/6 activation, and the repression of cyclin dependent kinase inhibitor by growth factor siganalling pathways becomes important.