Why can neomycin act as a potential inhibitor for flagellar regeneration?
In various organisms the flagella gets shed under stress condition (deflagellation) and newer ones are made immediately after this. The formation of the new flagella requires assembly of the microtubule system which makes up the flagella and the flagellar mRNA and protein. This entire procedure of deflagellation, mRNA accumulation and flagellar microtubule assembly has been seen to be regulated by the calcium signaling pathway involving different inositol phosphate and phospholipase C function. The stress condition leads to an accumulation of phospholipase C which stimulates flagellar excision.
Neomycin is a aminoglycoside antibiotic and a potent inhibitor of phospholipase C thus hampering the entire deflagellation pathway and thus block the regenration as well.
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