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What is NF?B and what is its role in mediating signals through TLRs?

What is NF?B and what is its role in mediating signals through TLRs?

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Answer #1

NF-kB, (nuclear factor kappa-light-chain-enhancer of activated B cells,
is a protein which regulates trascription as well as prodcution of cytokines in cells.
The protein complex plays an important role in regulating immune response.
TLRs are the recpetor proteins which activate the target proteins when bound by specific molecules.
When specific molecules like IKK complex binds to TLR, the downstream NFkB is activated
leading to transcription of specific genes.

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