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explain how mutation R or C subunits of cAMP dependent protein kinase PKA might lead to...

explain how mutation R or C subunits of cAMP dependent protein kinase PKA might lead to (a )constant active PKA and (b) constant inactive PKa

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Answer: As we know cAMP dependent protein kinase PKA is a tetramer having two regulatory and 2 catalytic subunits. The catalytic subunits are inhibited by the regulatory subunits. When regulatory subunits are dissociated from catalytic subunits they become active and this occurs with cAMP.

Constant inactive PKa; when there is a mutation in the allosteric site of regulatory subunits such that cAMP is unable to bind regulatory subunits, it leads a permanent association of C and R subunits and there is constant inactive PKa.

Constant inactive PKa; when there is a mutation in the allosteric site of catalytic subunits such that it is unable to bind regulatory subunit; it will lead to loss of inhibitory action of regulatory subunits to catalytic subunits. It will lead to constant inactive PKa

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