Question

Does Hyper-IgM Syndrome (yes/no)

a.     results from a defect in early B-cell maturation                  
b.     results in the production of large amounts of monoclonal IgM                   
c.      results from defective CD28 on his, is the igG defficiency protected by maternal transfer of igG?

Answer 1

Hyper-IgM Syndrome is the syndrome caused by the deficiency of the immunoglobulin results in the elevated levels of the IGM.

a.     results from a defect in early B-cell maturation - yes

Explantion: Autosomal recessive hyper-IGM results in the defect in the formation of the B-cell maturation.   
b.     results in the production of large amounts of monoclonal IgM - yes

Example:It is an immunoglobulin deficienct that results in the elevated levels of the IgM   
c.      results from defective CD28 on his, is the igG defficiency protected by maternal transfer of igG-yes

Example: tansplanation takes place.