Question

14. In an uncompetitive inhibition
    1. I binds to E                  c. I binds to P
    2. I binds to ES                      d. I binds to IP

15. In an irreversible inhibition, most likely there is formation between E and I of a(n)
    1. hydrogen bond                        c. hydrophobic bond
    2. covalent bond                                    d. electrostatic interaction

16. A recognition site is commonly present in the enzymes
    1. kinases                                     c. phosphatases
    2. proteases                                 d. cyclooxygenases

Answer 1

• Anti-competitive inhibition occurs if an enzyme inhibitor only binds to the complex formed between the enzyme and the substrate (the E-S complex) in a non-competitive inhibition. The correct option, is b.
• In an irreversible inhibition a(n)covalent bond is formed among E and I. Irreversible inhibitors react quickly with the enzyme but also chemically change it (e.g., through the formation of covalent bonds). The correct option, is b.  
• A recognition site is associated structurally with kinase enzymes. The correct option, is a.