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What would happen if you add a nuclear localization signal to the middle of a secreted...

What would happen if you add a nuclear localization signal to the middle of a secreted protein?
- It would be translated on the ER and targeted to the nucleus.

- It would be translated on the ER and secreted.

- It would be translated in the cytosol and secreted.

- It would be translated in the cytosol and imported into the nucleus.


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Answer #1

Nuclear localization signal is an amino acid sequence that tags a protein for import into the cell nucleus by nuclear transport.

Usually secretory proteins are translated and translocated on the ER (Endoplasmic reticulum) and as these proteins are sent to the ER while they are being translated, so also known as co-translational targeting.

As nuclear localization signal is added to the middle of a secreted protein :

It would be translated on the ER and targeted to the nucleus

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