Question

P87 is a proto-oncogene. What is the function of P87; and what is the effect of a mutation in the gene for P86 that decreases the efficiency of the P86 protein?

		move a cell past at a check point in cell cycle; increased chance of cancer
		halt a cell at a check point in cell cycle; decreased chance of cancer
		move a cell past at a check point in cell cycle; decreased chance of cancer
		halt a cell at a check point in cell cycle; increased chance of cancer

Answer 1

The P87 is a function protein of PI3K (Phosphoinositide 3-Kinase), which modify protein though posttranslational modification and categorized as pro-oncogenic if mutated. Another initiator protein P86, which is required for normal function of the cell if any mutation takes place in this gene then it can compromised the production of this protein and ultimately lead to cell cycle arrest (halt the cycle) and avoid the cancer formation. Hence, correct answer would be “halt a cell at a check point in cell cycle; decreased chance of cancer”.