Question

Which of the following is not possible for Robertsonian translocations:

Select one:

The formation of one large and one small chromosome

The formation of zygotes that are trisomic

The fusion of two acrocentric chromosomes

The fusion of two non-homologues chromosomes

The formation of zygotes that are monosomic

Answer 1

Ans. 4th option is incorrect.

Robertsonian Translocation is the most common chromosomal abnormality among humans ( 1 in every 1000 babies ). It causes reduction of chromosomes and result in genetic disorders such as Patau syndrome and Turners Down syndrome. The chromosomes are acrocentric and five pairs are involved in this translocation (13,14,15,21 and 22). Robertsonian translocation involves translocation of two homologous or two non-homologous pairs. Chromosomes are partitioned into a large part and a small part. This translocation results in trisomy 13 and trisomy 21.