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The plant toxin retinone blocks oxygen consumption by mitochondria. Addition of succinate restores oxygen consumption. Which...

The plant toxin retinone blocks oxygen consumption by mitochondria. Addition of succinate restores oxygen consumption. Which of the proton pumps of oxidative phosphorylation must be inhibited by retinone, therefore? Explain your answer.

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Answer #1

ANSWER: Rotenone is a broad spectrum insecticide and pesticide.

Mechansim of action of Rotenone: It interferes with the electron transport chain in the mitochondria. It inhibits Fe-S complex in the Complex-1 to the mobile electron carrier that is Ubiquinone.

Complex-1 is unable to pass the electrons to CoQ which results in accumulation of Oxygen in the mitochondrial matrix. This cellular oxygen is reduced to the free radicals which consequently result in the damage to DNA and other components of mitochondria.

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