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3. The enzyme phosphofructokinase PFK (PFK1) is the main control point in glycolysis. The reverse reaction,...

3. The enzyme phosphofructokinase PFK (PFK1) is the main control point in glycolysis. The reverse reaction, in gluconeogenesis, is catalyzed by the enzyme fructose bisphosphatase FBPase (FBPase1).

AMP and F 2’, 6’ bis phosphate are allosteric modulators of these two enzymes. Which enzyme is stimulated by these two small molecules, and which enzyme is inhibited?

Why is AMP a good indicator of the ATP level in the cell? What is the value of using F2’,6’bisP as a regulator?

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